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Longevity and Vielight Technology | Published Clinical Trials

Key takeaways:

  • Recharge Your Mitochondria: Aging brains suffer from an energy crisis. Vielight technology targets mitochondria, the cell’s powerhouses, to restore the ATP energy production vital for cognitive longevity.

  • The 810nm Advantage: Science shows that 810nm near-infrared light is the “sweet spot” for mitochondrial absorption versus other wavelengths.

  • Whole-Brain Synergy: Research from Baycrest and the University of Toronto confirms that Vielight’s patented transcranial-intranasal PBM approach activates global brain networks.

  • Backed by Clinical Data: From reversing signs of cognitive decline to improving recovery in TBI, our technology is validated by published trials in major medical journals.

When we talk about “brain longevity,” this refers to keeping our minds sharp, resilient, and energetic as we age. At the heart of this challenge lies a tiny cellular component: mitochondria.

Often called the “powerhouse of the cell,” mitochondria are responsible for producing ATP (adenosine triphosphate), the energy currency your brain needs to function. However, as we age, mitochondrial efficiency declines. This energy crisis is a key driver of cognitive decline, brain fog, and neurodegeneration.

But what if you could recharge these powerhouses using precision-based NIR light energy?

Proven by Science: Vielight Studies You Should Know

Brain Health: Proven Mitochondrial Effects with Vielight Technology

Our technology isn’t just longevity theory; it is backed by rigorous clinical research. Here are a few key studies highlighting the impact on longevity and cognition:

  1. Reversing Mitochondrial Dysfunction in MCI (2024): A University of Toronto clinical trial investigated the effects of Vielight’s itPBM on individuals with Mild Cognitive Impairment (MCI). After just 6 weeks, participants showed improvements in cognitive performance and, crucially, mitochondrial function, along with favorable changes in blood biomarkers linked to Alzheimer’s.

  2. Significant Cognitive Gains in TBI (2024/2025): Multiple studies from the University of Utah have shown that the Vielight Neuro Gamma can significantly improve executive function, reaction time, and balance in individuals with Traumatic Brain Injury (TBI), further validating the technology’s ability to repair and restore neural networks.

  3. Dementia Pilot Success (2015): In a landmark clinical trial, dementia patients using Vielight technology showed significant improvements in cognitive function and reduced wandering behaviors, with fMRI scans revealing increased functional connectivity in the brain’s Default Mode Network.

  4. Combatting “Brain Fog” & Neuroinflammation (Long COVID): A randomized, double-blind clinical trial (n=43) targeted the debilitating “brain fog” associated with post-COVID conditions using the Vielight Neuro Gamma. Participants—particularly those under 45—showed significant improvements in cognitive scores and attention tasks after just 8 weeks of home use. This study highlights the technology’s ability to reduce neuroinflammation and restore cognitive clarity after a major biological insult—a key capability for maintaining long-term brain health in a world of increasing viral stressors.
  5. Neuroprotection in Parkinson’s Disease. An n=14 proof-of-concept study involving patients with idiopathic Parkinson’s Disease tested the effects of the Vielight Neuro over 12 weeks. Participants experienced significant improvements in mobility, fine motor skills, and cognition. Remarkably, these improvements were sustained for up to one year with continued home use. This provides compelling evidence of neuroprotection—suggesting that PBM may help slow the progression of neurodegenerative processes and preserve motor and cognitive function as we age.
  6. “Tuning” the Brain: The Gamma Effect: Published in Nature Scientific Reports (2019), this pivotal study showed that a single 20-minute session with the Vielight Neuro Gamma significantly increased high-frequency brain oscillations (Alpha, Beta, Gamma) while reducing slow-wave activity (Delta, Theta). The device effectively “woke up” the brain, mimicking the high-energy states seen in long-term meditators and high-performers. This proves that Vielight technology doesn’t just heal; it optimizes. By enhancing Gamma synchrony, you are training your brain to maintain the high-functioning electrical signature of a younger, sharper mind.

Systemic Health: The “Whole Body” Effect (Verified by a Major Clinical Trial)

While brain longevity is the goal, your brain does not exist in a vacuum. It relies on a healthy body, robust circulation, and a strong immune system to function. This is where Vielight’s technology offers a distinct advantage through Systemic Photobiomodulation.

Vielight devices like the RX Plus don’t just target the brain; they utilize the dense capillary network in the nose to irradiate the blood circulating through the entire body.

The Evidence: The World’s Largest Successful PBM Trial The power of this systemic approach was proven in a major, peer-reviewed clinical trial involving 294 participants – the largest of its kind in the field of photobiomodulation.

  • The Challenge: The study focused on accelerating recovery from acute respiratory viral infections (specifically COVID-19) in patients with moderate-to-severe symptoms.

  • The Result: Participants who used the Vielight device within the first 7 days of symptoms recovered significantly faster than those who received standard care alone. The therapy effectively reduced respiratory symptoms, headaches, and body aches.

  • The Mechanism: Researchers attributed these results to the anti-inflammatory effects of PBM, which is known to lower cytokine levels (the molecules responsible for inflammation).

Why This Matters for Longevity: This trial led to the Vielight RX Plus receiving a Medical Device License from Health Canada for accelerating recovery from respiratory viral infections. For the longevity-focused individual, this validates that intranasal light therapy triggers a potent, body-wide biological response. By reducing systemic inflammation and supporting immune function, you are creating a healthier physiological environment for your brain to thrive.

The Vielight Neuro

The Vielight Neuro: Cognitive Longevity

As we age, the mitochondria in our neurons naturally degrade, leading to a “cellular energy crisis” that manifests as cognitive fog, slower processing, and memory lapses.

The Vielight Neuro (Neuro Pro 2, Alpha, or Gamma) is engineered to reverse this energy deficit using the science of photobiomodulation (PBM).

  • Targeting the Default Mode Network (DMN): The Neuro’s full transcranial modules are strategically positioned to focus on the DMN – a large-scale brain network crucial for memory and self-referential thought, which is often the first to show signs of decline in aging.

  • Deep Penetration: Utilizing high-irradiance 810nm LEDs (approx. 100 mW/cm²), the Neuro delivers photons through the skull to reach the cortical surface, while the patented intranasal applicator targets the ventral (underside) brain areas.

  • The Longevity Benefit: By regularly stimulating mitochondrial ATP production and increasing cerebral blood flow, the Neuro aims to build “cognitive reserve” – keeping neural networks robust, adaptable, and energized well into your later years.

The Vielight Vagus: HRV Enhancement for Longevity

Vielight Vagus: Systemic Resilience

Longevity requires a balanced body, not just a sharp mind. The Vielight Vagus targets the body’s main superhighway, the vagus nerve, to combat chronic stress and “inflammaging” (age-related inflammation).

  • Gentle & Non-Invasive: Unlike electrical devices that shock the nerve, the Vielight Vagus uses pulsed near-infrared light to safely stimulate the cervical vagus nerve, activating your “rest and digest” system.

  • The Longevity Benefit: Regular use supports Heart Rate Variability (HRV)—a key biomarker of biological youth. By improving HRV and dampening systemic inflammation, the Vagus helps your body bounce back from stress and maintains organ health as you age.

The Mitochondrial “Sweet Spot”: Why 810nm?

Not all light is created equal. When it comes to restoring mitochondrial function in the brain, precision matters.

In the world of brain photobiomodulation (PBM), there is an ongoing debate between using 810nm (near-infrared) versus longer wavelengths like 1064nm or 1070nm. While both have their proponents, the science points to 810nm as the superior choice for mitochondrial restoration.

Here is why 810nm wins the longevity argument:

  • Cytochrome C Oxidase (CCO) Peak: CCO is the enzyme inside mitochondria that accepts photons to boost energy production. Its absorption peaks near 810nm, making this wavelength the “mitochondrial sweet spot” for efficient ATP production.

  • Avoiding Water Absorption: Longer wavelengths like 1064nm and 1070nm face a significant hurdle – water. The human body (and brain) is abundant in water, which absorbs light heavily above 1000nm. This means less energy reaches your brain cells compared to 810nm, which passes through water with far less resistance.

  • Mechanism of Action: While 1064nm primarily affects heat-sensitive ion channels (a more experimental pathway), 810nm directly engages the mitochondrial respiratory chain. For consistent, proven neuroprotective benefits, 810nm remains the gold standard supported by the most published research.

The Irradiance Factor: Why Power Density Matters

Wavelength is the “key” to the cellular door, but irradiance (the intensity of the light) is the force required to turn it.

A common misconception in the industry is that “more LEDs = better results.” However, if those LEDs are too weak, the photons will scatter in the skin and skull, never reaching the brain. Conversely, if the light is too intense, it can cause thermal damage or inhibit cellular function—a phenomenon known as the biphasic dose response (or Arndt-Schulz Law).

Vielight technology hits a precise therapeutic window:

  • Penetration Power: In a published review study of over 2133 brain photobiomodulation studies, from which 97 studies were included, the average irradiance or power density was around 250 mW/cm2 . Vielight Neuro devices generate a power density of approximately 300-400 mW/cm2 : Link

  • The Goldilocks Zone: Our devices are tuned to be strong enough to trigger mitochondrial stimulation but gentle enough to avoid heating the brain. This balance ensures you get a “medicinal” dose of light without the risks associated with high-power clinical lasers or the ineffectiveness of weak cosmetic LEDs.

Delivery Matters: The Intranasal-Transcranial Advantage

Having the right wavelength is only half the battle; you also need to get that light into the brain. This is where Vielight’s patented Intranasal-Transcranial Photobiomodulation (itPBM) technology stands apart.

The skull is a formidable barrier to light. Traditional “helmet-only” devices struggle to penetrate deep enough to reach the inner structures of the brain. Vielight solves this by utilizing the intranasal channel.

  • The Cribriform Plate Shortcut: Inside the nasal cavity lies the cribriform plate, a paper-thin bone (only ~0.1mm thick) that separates the nose from the brain. It offers a direct highway to the prefrontal cortex and underside of the brain, bypassing the thick skull and hair that block other devices.

  • Whole-Brain Activation: A study conducted by Baycrest Hospital and the University of Toronto used fMRI to visualize this effect. They found that Vielight’s intranasal stimulation didn’t just affect the front of the brain—it triggered a rapid, global response, activating networks across both hemispheres in just 3 to 6 minutes [2].

By combining this intranasal delivery with transcranial (scalp) modules, Vielight devices ensure that light reaches both the cortical surface and the deeper, evolutionarily older parts of the brain.

Conclusion: The Future of Brain Health is Light

True longevity isn’t just about the lifespan of your body; it’s about the “healthspan” of your mind. As we have seen, maintaining cognitive function requires solving the cellular energy crisis that comes with aging.

Vielight distinguishes itself not by following trends, but by adhering to the rigorous physics of photobiomodulation. By targeting mitochondria with the optimal 810nm wavelength, ensuring effective skull penetration with high irradiance, and utilizing the intranasal pathway for direct brain and systemic access, our technology offers a comprehensive solution grounded in published science.

From the cellular engines in your neurons to the immune response in your blood, Vielight provides the energy your body needs to heal, restore, and thrive. You can’t stop time, but with the right light, you can definitely power up against it.

This article was written by

Dr. Genane Loheswaran

Vielight | Research Manager and Neuroscientist

Genane manages Vielight’s research projects with various organizations for cognitive science, such as combining photobiomodulation with EEG.

MSc in Neuroscience, McMaster University
PhD in Pharmacology, University of Toronto
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